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Review Article
DOI: 10.1016/j.jmrt.2018.03.007
“Smart” materials-based near-infrared light-responsive drug delivery systems for cancer treatment: A review
Ali Razaa, Uzma Hayatb, Tahir Rasheedc, Muhammad Bilald,
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Corresponding authors.
, Hafiz M.N. Iqbale,
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Corresponding authors.
a School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
b School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
c School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, China
d School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian 223003, China
e Tecnologico de Monterrey, School of Engineering and Sciences, Campus Monterrey, Ave. Eugenio Garza Sada 2501, Monterrey, N.L., CP 64849, Mexico
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Received 10 November 2017, Accepted 30 March 2018
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Tables (4)
Table 1. Carbon nanotube-based NIRDDSs.
Table 2. Gold nanomaterial-based NIRDDSs.
Table 3. ICG-based NIRDDS.
Table 4. Various types of DDSs based on photothermal agent, their notable characteristics, and applications.
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To overcome drawbacks of conventional chemotherapy for cancer treatment, stimuli-responsive drug delivery systems (DDSs) including internal and external stimuli-based cues are the potential candidates. Both internal and external stimuli-responsive behavior can be utilized for engineering of the so-called ‘smart’ DDSs. Drug release triggered by external stimuli is more controllable and avoid individual variability. Among them, light-responsive DDSs are more promising because of spatiotemporal control. With considerable penetration features, near-infrared (NIR) light is potential stimulus with clinical implication. There are three types of NIR-responsive DDSs (NIRDDSs) based on the mechanism, i.e., (1) photothermal effect, (2) two-photon absorption, and (3) up-converting nanoparticles (UCNPs). Photothermal effect-based DDS has been extensively studied because of their tunable optical properties and flexible surface chemistry. Carbon nanomaterials, gold nanomaterials, indocyanine green, and metallic sulfides/oxides are the commonly employed photothermal agents. Two-photon absorption-based DDSs provide higher excitation and overcome the drawback of UV/Visible light-sensitive DDSs of poor penetration. UCNPs are inorganic crystalline nanoscale particles (1–100nm) that exhibit photon up-conversion, i.e., conversion of NIR excitation light into UV/Visible emission light and empower deeper penetration into biological samples due to reduced light scattering. In this review, we discussed different NIRDDSs. The emphasis was also given to their drug release mechanisms and applications in the treatment of cancer.

Drug delivery systems
Photothermal therapy
Photothermal agents
Two-photon absorption
Up-converting nanoparticles
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Cancer is one of the major health problems and is a leading cause of death [1]. In 2017, around 600920 deaths are projected only in the United States [2], due to cancer. Conventional treatments, i.e., chemotherapy and radiotherapy, are considered not to be very effective due to lack of specificity and toxicity [3–6]. Thus, the development of targeted drug delivery systems (DDSs) for tumor treatment is a hot research area. Nanotechnology-based DDSs such as polymeric nanoparticles, liposomes, micelles, etc. are considered as potential DDSs due to enhanced permeability and retention effect, enhanced half-life, better bioavailability, and higher targeting ability by the addition of aptamers [3,7,8]. However, premature drug release and insufficient drug release at target sites are major limitations for such drug delivery [9,10]. Stimuli-responsive drug delivery systems (SRDDSs) are considered to be effective in overcoming these limitations [3–6,9–11]. SRDDS release the loaded drug under the influence of a particular stimulus. These are also termed as intelligent or smart DDSs because of on-demand drug delivery property [12]. These stimuli can be internally based on the difference in the environment of tumor tissue and normal tissue or can be external [12–14].

Internal stimuli include pH, temperature, hypoxia, enzymatic activity, and glutathione (GSH) concentration. Tumor tissue has low pH (6.5), high temperature (40–42°C), higher GSH concentration (reductive environment) and specific enzymes overexpression (e.g., matrix metalloproteinases, cathepsin, urokinase plasminogen activators) when compared to normal tissue. So DDSs that can release the loaded drug in response to these stimuli can be used to targeting tumor tissue and have shown specificity with low toxicity [9,14,15]. However, inter-individual variability, limited control over drug release, and difficulty in preparation of such systems that can respond to such narrow limits are limitations for such DDSs [16,17]. External stimuli such as light, magnetic field, electric field, and ultrasound-responsive DDSs have been reported to be successful in overcoming igniter-individual variability as drug release is controlled external stimuli which are controllable when compared to internal stimuli [6,10,11,18]. Among these external stimuli, light is considered as an attractive external stimulus due to ease and better spatiotemporal control [19]. Among different developed light-responsive DDSs, most of them respond to UV light which has disadvantages of not only poor tissue penetration, but also harmful to cells and tissues. Due to these drawbacks, UV light-responsive systems are difficult to bring in clinical practice [10]. However, near-infrared (NIR) light with a wavelength of 650–900nm has good tissue penetration due to limited attenuation and is also safe for cells and tissues [10,20,21]. Therefore, NIR-responsive systems are potential carriers for drug delivery in targeted site for clinical applications [22].

NIR-responsive systems release drug upon exposure to NIR light which is resulted by photothermal effect, leading to an increase in temperature. This increase in temperature can also cause cell death (photothermal treatment) which synergies drug action [23,24]. Other mechanisms involved two-photon conversion and UCNPs [10,24]. The later one is also used to deliver photosensitive material as a source for photodynamic therapy [25,26]. Based on these mechanisms, multi-modal carriers have also been developed which contribute to drug release, photothermal therapy, and photodynamic therapy [27,28]. This review will cover mechanism of drug release from NIRDDSs and their reported applications in the treatment of cancer by different types of drug carriers. We also discussed multimodal systems based on NIR response such as imaging, photothermal, and photodynamic therapy along with multi-responsive DDSs.

2Design strategies and mechanisms of drug release

There are three reported mechanisms for drug release from NIRDDSs, i.e., (a) photothermal effect (PTE) (b) two-photon absorption (TPA), and (c) Up-converting nanoparticles (UCNPs) [10]. A scheme of these mechanisms is given in Fig. 1. Out of these mechanisms, photothermal effect-based drug release systems were widely explored with or without photothermal therapy. Thermo-responsive materials are employed for the preparation of such systems. These systems generate heat after absorbing NIR light, and this increase in temperature will enhance the drug release whether by phase change mechanism or by disruption of the structure of drug carriers. High temperature (hyperthermia) also has cytotoxic effect, so photothermal therapy can also be observed in such systems along with chemotherapy (chemo-photothermal therapy) [6,29,30]. Carriers for designing this kind of DDSs should have strong absorption in NIR range for efficient photothermal conversion, efficient tumor homing capacity after intravenous administration, biodegradability, and safety [31]. As already discussed, UV and visible light-responsive systems have limited clinical implications because of poor penetration and harmful effects of UV light. This problem can be overcome by using two-photon absorption, for instance, [7-(diethylamino) caoumarin-4-yl]methyl (DEACM) is a photo-cleavable group via single-photon UV light. However, two-photon absorption can also promote the same cleavage reaction of DEACM [32]. Hence, such UV light-sensitive material having ability to undergo two-photon absorption in NIR range may be extended for clinical implications. In another report, micelles composed of hydrophilic polyethylene oxide (PEO) and hydrophobic poly(2-nitrobenzyl methacrylate) were found to have photo-induced disruption with a single photon in UV range (350nm) or two-photon NIR (700nm) [33]. FRET (Förster/fluorescence resonance energy transfer) phenomenon by two-photon excitation can also be used for activation of photo-labile moieties in which a fluorophore absorb two-photon and transfer energy to activate light-sensitive compounds [34]. UCNPs can convert NIR into high-energy photons in UV and visible range. These nanoparticles are usually made of lanthanides-based nanomaterials that can absorb multiple low-energy photons in NIR range and convert them into high-energy photons in a visible or UV range which can be further used to activate photochemical reaction for promoting drug release or to activate photosensitizers for photodynamic therapy (PDT). UCNPs overcome UV light-responsive drug delivery drawbacks such as poor penetration and toxicity of UV light exposure [10]. There are three ways for the development of UCNPs for drug delivery. (i) Hydrophobic pockets which involve encapsulation of hydrophobic drug intro hydrophobic pockets present on UCNPs by the hydrophobic–hydrophobic attraction between hydrophobic ligand and drug. (ii) Mesoporous silica shells coated UCNPs which offers a large surface area for drug deposition, (iii) Drugs loaded in hollow spheres with mesoporous surface [35]. PDT involves photosensitizer that produces singlet oxygen (SO) and reactive oxygen species (ROS) upon light exposure usually of high energy which has a limitation in clinical implications. Using UCNPs, emitted visible light can be utilized for activation of photosensitizer for PDT [25].

Figure 1.

A scheme of three mechanisms of NIRDDSs.

3Photothermal effect-based NIRDDSs

Light to heat conversion upon NIR irradiation by NIR absorbing materials can cause drug release from a thermo-responsive drug carrier. Different materials have been reported having the ability to convert NIR light into heat (photothermal property) such as carbon nanomaterials (graphene oxide and carbon nanotubes), gold nanomaterials (such as nanoparticles, nanorods, and nanocages), metallic oxides/sulfides, indocyanine green dye, melanin, polyaniline, etc. [10,36].

3.1Graphene-based NIRDDSs

Graphene is hydrophobic in nature and its dispersion in blood is difficult. However, functionalization with polymers can enhance its dispersibility. Moreover, a DDS based on graphene oxide (GO) has been prepared by oxidation of graphene using exfoliation technique. The GO has property to bind to drugs by covalent bond due to free carboxylic and hydroxyl groups, by adsorption of drugs, by hydrophobic attraction, and by π–π hydrogen bonding [37,38]. These free functional groups can also be used for binding with targeting proteins (antibodies) to develop targeted delivery systems and with other material to form nanocomposites [39]. Such modification with nontoxic polymers enhances its biocompatibility. GO has the property to generate heat efficiently after absorbing NIR light leading to hyperthermia [40]. This property has been utilized by many researchers for drug delivery and photothermal treatment. Recently, Zeng et al. [41] have reported multifunctional nanographene oxide carriers for gene and drug delivery. A combination of chemo, gene, and photothermal therapy showed the synergistic effect to overcome drug resistance. Folate-targeted polyethyleneimine (1800)-modified PEGylated nanographene (PPG) was used to load both siRNA and doxorubicin. NIR irradiation exhibited enhanced doxorubicin release when compared to without NIR irradiation. In another study, Bani et al. [42] developed nano-graphene-polyglycerol-curcumin hybrids for chemo-photothermal therapy. Non-covalent functionalization of nano-graphene with polyglycerol increased the dispersibility of nano-graphene for a longer duration as no aggregation was reported up to several weeks. Furthermore, an increase in the release of curcumin from 6 to 29% was reported after NIR irradiation after predetermined time intervals over 48h. Synergistic effect of photothermal with chemotherapy was observed by in vitro cytotoxicity studies in MCF7 cancer cells. Graphene oxide can also be used to prepare multi-responsive systems such as responsive to both pH and NIR light. Doxorubicin-loaded nanographene oxide flakes incorporated with chitosan-PEG were synthesized by Thapa et al. [43] (Fig. 2a). These flakes showed a pH- and NIR-responsive doxorubicin release (Fig. 2b). In vivo experiments showed hyperthermic effect (32.3–43.1°C after 5min NIR irradiation) at tumor site when compared to control (Fig. 2c). Furthermore, synergistic activity of photothermal effect of nanographene oxide and chemotherapy with doxorubicin was observed by comparing tumor volume after treatment (Fig. 2d). Hence, nanographene/nanographene oxide can be used for drug/gene delivery to have chemo and gene therapy with photothermal therapy.

Figure 2.

(a) Single-pass gas-phase self-assembly of nanodimensional graphene oxide (nGO)-incorporated doxorubicin (DOX) (nGO@DOX) flakes from incorporation of nGO flakes and DOX droplets and subsequent solvent extraction from the hybrid droplets. The assembled nGO@DOX flakes were incorporated with chitosan-polyethylene glycol (cPEG) in the liquid phase before application in anticancer activity analysis. (b) In vitro release profiles of DOX at different pH conditions (P<0.01). (c) In vivo photothermal imaging upon NIR laser irradiation on tumors of mice pretreated with saline or nGO@DOX-cPEG. cPEG, chitosan-polyethylene glycol; Cy5.5, cyanin 5.5; DOX, doxorubicin; nGO, nanodimensional graphene oxide; NIR, near-infrared. (d) Tumor volume after IV administration of different samples (control, DOX, nGO@DOX-cPEG, and nGO@DOX-cPEG. Reproduced from Ref. [43], an article licensed published by Nature Publishing Group under a Creative Commons Attribution 4.0 International License,

3.2Carbon nanotube-based NIRDDSs

Biomedical applications of carbon nanotubes have been explored widely including DDS and photothermal treatment because of strong light to heat transducing ability, chemical stability, robustness, high drug binding site, and ability to penetrate through the cell membrane. However, like graphene, carbon nanotubes have dispersibility problem and cytotoxicity which can be overcome by functionalization [36,44]. In a recent report, Dong et al. [45] utilized functionalized multiwalled carbon nanotubes with TAT-chitosan (TC) conjugate for enhancing cytocompatibility. Further, they loaded doxorubicin to evaluate the prepared system as an NIR-triggered drug release system along with photothermal therapy. Maximum release of doxorubicin was observed with NIR irradiation at pH 5.5, which also indicated that release behavior was pH-dependent. TC coating decreased the release rate, but enhances cell internalization when compared to without TC-coated systems. Overall results showed the synergistic effect of chemotherapy and photothermal therapy of prepared nanosystems which efficiently ablated tumor in animal models. Yoo et al. reported the enhanced efficacy of metformin against tumor cells by hyperthermia induced by multiwalled carbon nanotubes. With metformin cell viability of HepG2 cells decreases to 24% when compared to without metformin carriers. Hydrogels are semisolid three-dimensional polymeric networks having a large volume of water/biological fluid and is considered an attractive system for drug delivery due to biocompatibility. Stimuli-responsive hydrogels underwent structural disruption leading to release of the enclosed drug [44]. In this regard, thermo-responsive doxorubicin-loaded PCL-PEG-PCL hydrogel was reported by Dong et al. [45], which was combined with carbon nanotubes to establish an on-demand drug release system. On-demand release, controllable through NIR irradiation was observed in in vivo studies. Some other reported drug delivery carriers based on carbon nanotubes are summarized in Table 1.

Table 1.

Carbon nanotube-based NIRDDSs.

System  Functionalization  Drug loaded  Modality/(ies)  Ref. 
Nanostructures  PEG-NH2,
ssDNA-caged aptamer 
Doxorubicin  Dual-targeted NIR-responsive drug delivery, photothermal therapy  [46] 
Microcapsules  Poly(diallyl dimethyl ammonium chloride)  Doxorubicin  NIR-responsive DDSs  [47] 
Prodrug on single-walled carbon nanotubes  PEG  Doxorubicin  pH/NIR dual responsive drug delivery, photothermal therapy  [48] 
Single-walled carbon nanotube-based nanocarriers  Poly(ethyleneimine), NGR  Doxorubicin  pH/NIR dual responsive drug delivery, photothermal therapy  [49] 
Mesoporous silica-coated carbon nanotubes  PEG  Doxorubicin  NIR-responsive drug delivery, photothermal therapy  [50] 
3.3Nanomaterial-based NIRDDSs

In recent years, numerous materials have been used to construct different drug delivery carriers using nanoscale-level including nanoparticles, nanorods, nanocages, nanocubes, etc. [51–53]. Nanomaterials with special reference to gold-oriented nanoparticles tend to convert NIR light to heat efficiently even several times higher when compared to photothermal dyes due to surface plasmon resonance phenomenon. Secondly, readily attachment of antibodies and other biological macromolecular agents makes it a potential candidate for therapeutic applications [10,51]. Furthermore, they are biocompatible and chemically inert [52]. Among different gold nanomaterials, gold nanoparticles, and nanorods are potential ones due to proficient large-scale production, high optical absorption coefficient, and tunable absorption range [53]. For instance, Yang et al. [52] reported a dual responsive (redox and NIR light) drug release system of doxorubicin-loaded mesoporous silica with gold nanoparticles embedded in pores of mesoporous silica to attain chemo-photothermal therapy. In vitro cytotoxicity studies on A549 cells of these nanocarriers showed the synergistic effect of chemo- and photothermal therapy. An enhanced doxorubicin release was observed from these nanocarriers in the presence of GSH and NIR irradiation illustrating a potential of controlled release systems. In another study, Haine et al. [54] utilized the photothermal effect of gold nanoparticles for enhancement of protein-based drugs through the skin using thermal ablation. Furthermore, doping of gold nanorods in a thermo-responsive hydrogel with subsequent NIR irradiation would stimulate drug release embedded in the hydrogel. For instance, Qu et al. [55] synthesized PCNA thermo-responsive hydrogel loaded with doxorubicin and gold nanorods (DOX-PCNA-GNR) to inhibit post-operative breast cancer relapse (Fig. 3). After NIR irradiation, constriction of hydrogel was reported to be responsible for drug release. In vivo studies in 4T1 cells orthotopic tumor-bearing mice, significant suppression of recurrence rate by DOX-PCNA-GNR hydrogel and NIR irradiation was reported. Also, the hydrogel was found to be biodegradable/biocompatible when implanted subcutaneously in the rat (Fig. 4). Numerous other studies are recently reported on the application of gold nanomaterials for chemo-photothermal therapy (Table 2).

Figure 3.

Schematic illustrating that the reticulate cubic structure was denser with smaller pore sizes and increased DOX release after 808nm laser excitation. Reproduced from Ref. [55], an article licensed published by Nature Publishing Group under a Creative Commons Attribution 4.0 International License,

Figure 4.

(A) DOX-release profiles in the presence and absence of NIR laser at pH 5.0 and 7.4. (B) Cytotoxicity at different concentrations of PCNA-hydrogel leachate. The composite exhibited no cytotoxicity and the NIH 3T3 cells proliferated as well as when treated with the negative control. (C) In vivo persistence and histology sections from subcutaneous rat tissue after implantation of PCNA-hydrogel composites for different periods. Images in panels a (e), b (f), c (g), and d (h) were captured at 7, 14, 28, and 35 days, respectively (scale bar: 200μm). Reproduced from Ref. [55], an article licensed published by Nature Publishing Group under a Creative Commons Attribution 4.0 International License,

Table 2.

Gold nanomaterial-based NIRDDSs.

Gold nanomaterial  Delivery system  Drug-loaded  Modality/(ies)  Evaluation method  Ref. 
Gold nanoshell  Gold nanoshell-coated chitosan liposomes  Resveratrol  pH-NIR responsive drug delivery, chemo-photothermal therapy  In vitro HeLa cells  [56] 
Gold nanorods (GNR)  GNR@mesoporous silica/poly(N-isopropylacrylamide-co-N-hydroxymethyl acrylamide) nanocomposites  Doxorubicin  Thermo/NIR-responsive drug delivery, chemo-photothermal therapy  In vitro U87 cells  [57] 
Gold nanocages  Biotin-PEG-modified gold nanocages  Doxorubicin and quercetin  NIR-responsive drug delivery  In vitro MCF7/ADR  [58] 
Gold nanoshells  Phospholipid liposomes  Betulinic acid  NIR-responsive drug delivery, chemo-photothermal therapy  In vitro 143B cells and HeLa cells  [59] 
Gold nanorods  GNR-embedded Diblock copolymer [PEG-b- poly(2-hydroxyethyl acrylate)–lipoic acid–folic acid] micelles
GW627368X  Redox/NIR-responsive drug delivery, chemo-photothermal therapy  In vivo studies on S180 bearing swiss albino mice, in vitro studies on SiHa,ME180, HaCat, and 3T3  [53] 
Gold nanorods  Dopamine-adipic acid dihydrazide-hyaluronic acid trifuncitionalized gold nanorods  Doxorubicin  CD44-targeted NIR-responsive drug delivery, chemo-photothermal therapy  In vivo studies on tumor-bearing mice, in vitro studies on MCF-7 cells  [60] 
Gold nanorods  N-isopropylacrylamide (NIPAM) and methacrylated poly-β-cyclodextrin (MPCD)-based PEG-GNR nanocomposite hydrogel  Doxorubicin  pH-NIR responsive drug delivery, chemo-photothermal therapy  In vitro studies on MCF-7 and HeLa cells, in vivo evaluation on S180 tumor-bearing mice  [61] 
Gold nanorods  Poly(sodium 4-styrene sulfonate) gold nanorods  Doxorubicin  NIR-responsive drug delivery, chemo-photothermal therapy  In vitro evaluation performed on MCF-7, in vivo studies using Dalton lymphoma ascites bearing swiss albino mice
Gold nanorods  Carbon core-shell based GNR nanocapsules  Doxorubicin  NIR-responsive drug delivery, chemo-photothermal therapy, fluorescence imaging  In vitro studies on MCF-7  [63] 
3.4Indocyanine green dye-based NIRDDSs

Indocyanine green (ICG) is an NIR absorbing dye, and only US-FDA approved NIR organic dye. Absorption and emission range fall in the NIR region of about 740–800nm [64]. Due to its ability to switch absorbed NIR light to heat, it is widely explored for photothermal therapy and developing NIRDDSs based on photothermal effect [65]. However, some of its properties limit its applications such as poor aqueous solubility, aqueous degradable, rapid clearance from the body (half-life of about 2–4min), agglomeration in an aqueous medium, photoinstability, non-specific protein binding, and lack of targeting [64,66]. Using nanotechnology, several attempts have been made to surmount these limitations, for instance, poly(lactic-co-glycolic acid) [PLGA] encapsulating ICG nanoparticles are reported to not only increase stability in an aqueous medium, photo, and thermal stability, but also increase half-life [67]. In another study, colloidal poly(¿-caprolactone)-coated silica nanocomposite encapsulating ICG were reported to enhance photo and aqueous stability of ICG [68]. Moreover, functionalization of nanoparticles encapsulating ICG with targeting molecules can be used to target tumor cells, e.g., anti-HER2 antibody for targeting HER2-positive breast cancer [69], anti-EGFR antibodies against EGFR-rich tumor [70], and floated grafted nanoparticles [71]. In addition, many NIR-responsive DDSs employing ICG for its photothermal property have also been reported (Table 3). Self-co-assembled nanoparticles of ICG and Epirubicin (EPI) were prepared by Li et al. [72] for chemo-photothermal therapy and dual modal imaging, i.e., near-infrared fluorescence (NIRF) imaging and photoacoustic imaging (PA). Hydrophilic epirubicin hydrochloride was transformed into hydrophobic EPI by removal of HCl. Then nanoparticles were prepared by drop-wise addition of an organic solution of ICG and EPI in aqueous solution with stirring and ultrasonication. In vitro studies indicated good physical stability with no significant particle diameter change for up to 7 days and photothermal effect to reach 57°C after 5min laser irradiation when compared to 48°C with ICG alone. Further, accelerated drug release was found at pH 5.0 due to protonation of EPI and after NIR irradiation. In vitro cellular uptake studies in 4T1 and MCF-7 cells showed enhanced uptake of nanoparticles and retention. In vivo treatment of 4T1 breast cancer-bearing BALB/c nude mice with ICG/EPI nanoparticles with NIR irradiation showed a reduction of tumor volume and relative tumor volume to normal in 20 days with no toxicity as depicted by biochemical and histopathological studies. In another report, anti-HER-2/ICG-DOX_PEF-PLGA diblock copolymeric nanoparticles (HIDPPNPs) were developed by Lee et al. [73] through solvent evaporation method followed by conjugation with antibody using carbodiimide linker. Prepared targeted nanoparticles showed twofold increase uptake by HER-positive breast cancer cells when compared to HER negative cells. Cytotoxicity studies performed on MDA-MB-453 showed HIDPPNPs with a 3μM concentration of DOX had maximum cytotoxicity efficacy after NIR light irradiation.

Table 3.


Carrier system  Functionalization  Drug-loaded  Modality/ies  Evaluation  Ref. 
Cell membrane capsules  –  Doxorubicin  NIR-responsive drug delivery, photothermal therapy  In vivo studies on tumor-bearing mice, in vitro evaluation performed using HepG2 cells  [74] 
Nanoparticles  Chitosan-N-arginine conjugate  Doxorubicin  Chemo-photothermal therapy  In vitro studies on MCF7/ADR breast cancer cells  [75] 
Nanoparticles  1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-maleimide (polyethylene glycol 2000) [DSPE-PEG], PLGA  Doxorubicin  NIR-responsive drug delivery, photothermal therapy  In vivo studies on tumor-bearing Balb/c nude mice. In vitro evaluation of MCF7 and MCF7/ADR cells  [76] 
Hybrid bicelles  DSPE-PEG2000  Doxorubicin  Chemo-photothermal therapy, fluorescence imaging  In vivo studies on 4T1 tumor-bearing Balb/c nude mice. In vitro evaluation of MDA-MB-231 cells  [77] 
Liposomes  DSPE-PEG2000  Doxorubicin    In vivo studies on MCF7 tumor-bearingbalb/c nude mice, in vitro evaluation performed using MCF7 cells  [78] 
3.5Other materials-based NIRDDSs

Several other materials having ability to convert NIR light into heat have also been investigated for fabrication of NIRDDSs and photothermal therapy such as different metallic sulfides/oxides, organic conjugated molecules, and melanin. A few reported applications of these materials in connection with NIRDDS/photothermal therapy are summarized in Table 4.

Table 4.

Various types of DDSs based on photothermal agent, their notable characteristics, and applications.

Photothermal agent  Delivery system  Drug-loaded  Characteristics  Applications  Ref. 
Copper sulfide (CuS)  CuS@mesoporous silica-PEG core–shell nanoparticles  Doxorubicin  Size of nanoparticles is about 37nm with colloidal stability due to PEG. 200μl/ml concentration showed a temperature rise from 20 to 40.4°C of water after 360s irradiation. No toxic effect up to 500μg/ml in HeLa cells indicating biocompatibility of nanoparticles  NIR-responsive drug delivery combined with photothermal therapy  [79] 
CuS  Hollow material copper sulfide nanoparticles conjugated with hyaluronic acid (HA)  Doxorubicin  The average size of DOX-loaded nanoparticles was 113.8±6.9nm, significant increased cellular uptake found in MCF7 cells due to CD44 receptor targeting by HA, ROS generation  Targeted/NIR-responsive drug delivery with photothermal therapy  [80] 
Ferric oxide (Fe3O4Meso-2,3-dimercaptosuccinic acid (DMSA) functionalized nanoparticles  Doxorubicin  Average size of DOX-loaded NPs was 102.02±0.597nm with photothermal conversion efficiency of about 21.85%, NIR triggered cellular uptake, ROS production with NIR irradiation
pH/NIR responsive drug delivery with photothermal therapy, PDT  [81] 
Polypyrrole  Polyacrylic acid-coated PPY/florescent mesoporous silica core–shell nanoparticles  Doxorubicin  The average size of NPs was 150±5nm with the photothermal efficiency of 31.3% having the ability to cause hyperthermia (42°C) at 0.250mg/ml. Excellent cellular uptake  pH/NIR-responsive drug delivery with photothermal therapy, imaging
Black phosphorus  Nanosheets  Doxorubicin  High drug loading capacity, ROS generation ability, biocompatible (4T1, HeLa, L929, and A549 cells)  Chemo-photothermal therapy, PDT, NIR-responsive drug release system  [82] 
Molybdenum disulfide (MoS2)  Chitosan functionalized MoS2Nanosheets  Doxorubicin  Average size was about 80nm with the photothermal efficiency of about 24.37%. Biocompatible (studied in KB and Panc-1 cells)  NRDD, photothermal therapy  [83] 
4Two-photon absorption-based NIRDDSs

One of the drawbacks of light-responsive DDSs is that many such systems required UV or visible light for activation which has the limitation of poor tissue penetration. Two-photon absorption in NIR range provides an opportunity to resolve this issue, as NIR light have better tissue penetration and safety profile [10]. For instance, azobenzene moieties undergo reversible cistrans isomerism under UV irradiation (300–380nm) which can alter structures having these moieties. Such structural changes have been utilized to design on-demand UV light-responsive DDSs [84]. To utilize these systems clinically, some efforts have been made to activate such moieties by employing NIR light. For instance, Croissant et al. [34] developed two-photon triggered drug release system-based mesoporous silica nanoparticles with fluorophore nanovalves. For this, they developed a novel paracyclophane-based fluorophore which could absorb two photons in NIR region and transfer energy through FRET to azobenzene part of valves, which upon cistrans isomerization open valves to release enclosed drug (camptothecin). Camptothecin-loaded nanoparticles irradiated with a laser of 760nm with maximum power showed 30% cell death, while without irradiation no significant cell death observed, indicating the success of the developed particles. Previously, the same research group also reported two-photon excitation-based nanoimpellers for drug release lying on the same principle of FRET [85]. Recently, novel nitrogen-doped and surface-passivated carbon nanodots for NIRDDSs based on two-photon absorption principle were reported by Ardekani et al. [86]. Prepared carbon nanodots exhibited NIR-responsive doxorubicin release along with photothermal cell killing in in vitro evaluation using MCF7 cells. Carbon nanodots can also be used as a donor of FRET for activating photosensitizers to promote PDT [87].

5Up-converting nanoparticles

UCNPs can convert NIR light into high-energy UV/visible light. This emitted high-energy light has recently increased interest for utilization in the development of nanomaterials based on UCNPs for drug delivery, PDT, and biomedical imaging. Lanthanide/rare earth metals are commonly employed for up-conversion of energy. High-energy photon emitted by up-conversion can be used to promote photochemical reaction on the surface or within polymer-coated UCNPs passing up drawbacks of high-energy light [7]. Liu et al. [88] reported NaYF4:TmYb core-shell UCNPs coated with mesoporous silica. Azobenzene groups were installed in mesoporous silica, and nanoparticles were further functionalized by TAT protein for enhancement of cellular uptake and loaded with anticancer drug (doxorubicin). Conversion of azobenzene to trans-configuration upon UV light absorption leads to the release of the drug. Irradiation of NIR light at 980nm leads to the emission of UV light from UNCPs which was absorbed by azobenzene group triggering drug release. Cytotoxicity studies on HeLa cells showed good cytocompatibility of nanoparticles without the drug. However, the significant cell killing ability was reported with DOX-loaded nanoparticles with NIR irradiation. UV/visible up-converted light can also be used to activate photosensitizers to generate ROS for PDT. Hu et al. [89] developed nanodumbles composed of UCNPs (NaYF4:Yb:Er) covered with amphiphilic lipid (octadecyl-quaternized polyglutamic acid) and polystyrene-block-poly(acrylic acid) for enhancement and attachment of photosensitizer (zinc (II) phthalocyanine). NIR irradiation and the presence of photosensitizers were found necessary for ROS generation to promote cytotoxicity. In another study [90], NIR responding multifunctional nanoimpellers for simultaneous chemo and PDT was developed. Nanoimpellers were composed of NaYF4:Yb, Tm@0.6(NaYF4: Yb, Er) upconverting nanocrystals coated with mesoporous silica (mSiO2) conjugates with Rose bengal (RB) and 4-phenylazobenzoyl (azo) loaded with doxorubicin (Fig. 5). NIR light (980nm) was reported to activate nanoimpellers upconverting nanocrystals for emission of high-energy photon that was absorbed by the azo group and RB, resulting in drug release and ROS generation. Cytotoxicity showed the synergistic effect of PDT and chemotherapy.

Figure 5.

(A) Synthetic procedure of Dox-loaded UCN@mSiO2-(Azo+RB) nanoparticle. (B) The upconversion emission spectrum of core–shell UCNs and UV–vis absorption spectra of pure Rose Bengal and azobenzol. (C) Chemical structures and synthetic procedures of the nanoparticles. Reproduced from Ref. [90], with permission from Elsevier.

6Concluding remarks

In this review, we have covered different mechanistic approaches of NIR-responsive DDSs. NIR light is a promising external stimulus due to its tissue penetration and unharmful. Photothermal and PDT are often found in conjunction with such delivery systems having a synergistic antitumor effect. Due to prevailing resistance to chemotherapy, external stimuli triggered drug delivery with synergistic photothermal, and PDT is found potential approach when compared to conventional therapy. However, biocompatibility/biodegradability of nanomaterials (especially inorganic nanoparticles) used in such delivery systems must be considered for clinical implications.

7Conflicts of interest

The authors declare that they have no conflict of interest.


We acknowledge Shanghai Jiao Tong University, China, School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian 223003, China, and Tecnologico de Monterrey, Mexico for providing literature access.

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